Assay Detail
Binding
CHEMBL681289
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Inhibition of rate of incorporation of [3H]FPP into recombinant Ras-CVIM by human farnesyltransferase.
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Diaryl ether inhibitors of farnesyl-protein transferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.14 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24888 | — | — | 1 | 9.00 |
| CHEMBL22959 | — | — | 1 | 8.96 |
| CHEMBL282499 | — | — | 1 | 8.54 |
| CHEMBL22319 | — | — | 1 | 8.10 |
| CHEMBL22819 | — | — | 1 | 8.02 |
| CHEMBL22440 | — | — | 1 | 7.89 |
| CHEMBL282001 | — | — | 1 | 7.85 |
| CHEMBL25606 | — | — | 1 | 7.77 |
| CHEMBL22710 | — | — | 1 | 7.57 |
| CHEMBL22080 | — | — | 1 | 7.57 |
| CHEMBL25500 | — | — | 1 | 7.55 |
| CHEMBL423109 | — | — | 1 | 7.42 |
| CHEMBL25542 | — | — | 1 | 7.42 |
| CHEMBL25439 | — | — | 1 | 7.42 |
| CHEMBL23019 | — | — | 1 | 7.42 |
| CHEMBL22826 | — | — | 1 | 7.40 |
| CHEMBL22235 | — | — | 1 | 7.39 |
| CHEMBL25217 | — | — | 1 | 7.35 |
| CHEMBL22847 | — | — | 1 | 7.28 |
| CHEMBL22547 | — | — | 1 | 7.07 |
| CHEMBL22854 | — | — | 1 | 7.00 |
| CHEMBL22718 | — | — | 1 | 6.96 |
| CHEMBL23011 | — | — | 1 | 6.89 |
| CHEMBL277489 | — | — | 1 | 6.82 |
| CHEMBL280905 | — | — | 1 | 6.75 |
| CHEMBL22568 | — | — | 1 | 6.70 |
| CHEMBL24985 | — | — | 1 | 6.64 |
| CHEMBL25602 | — | — | 1 | 6.64 |
| CHEMBL279066 | — | — | 1 | 6.54 |
| CHEMBL25550 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24888 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL22959 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL282499 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL22319 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL22819 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL22440 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL282001 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL25606 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL22710 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL22080 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL25500 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL423109 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL23019 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL25439 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL25542 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL22826 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL22235 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL25217 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL22847 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL22547 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL22854 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL22718 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL23011 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL277489 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL280905 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL22568 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL24985 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL25602 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL279066 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL25550 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL280384 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL22800 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL22356 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL22454 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL283323 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL279923 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL22238 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL22659 | — | IC50 | < | 1.0 | nM | - |