Assay Detail
Binding
CHEMBL681339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of estrogen sulfotransferase (EST) in TLC radiolabel transfer assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of estrogen sulfotransferase inhibitors from a purine library screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.51 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76784 | — | — | 1 | 6.30 |
| CHEMBL91816 | — | — | 1 | 4.52 |
| CHEMBL89567 | — | — | 1 | 4.52 |
| CHEMBL90592 | — | — | 1 | 4.46 |
| CHEMBL89926 | — | — | 1 | 4.22 |
| CHEMBL93782 | — | — | 1 | 4.22 |
| CHEMBL90365 | — | — | 1 | 4.22 |
| CHEMBL76921 | — | — | 1 | 4.10 |
| CHEMBL316097 | — | — | 1 | 4.00 |
| CHEMBL91450 | — | — | 1 | - |
| CHEMBL92115 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76784 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL91816 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL89567 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL90592 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL89926 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL93782 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL90365 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL76921 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL316097 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL91450 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL92115 | — | IC50 | > | 200000.0 | nM | - |