Assay Detail
Binding
CHEMBL681438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GAR transformylase from mammalian L1210 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Trifunctional purine biosynthetic protein adenosine-3 (CHEMBL3690) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.20 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267890 | — | — | 1 | 6.30 |
| CHEMBL66389 | — | — | 1 | 4.10 |
| CHEMBL66864 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267890 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL66389 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL66864 | — | IC50 | > | 20000.0 | nM | - |