Assay Detail
Binding
CHEMBL681444
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | lymphoma |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Trifunctional purine biosynthetic protein adenosine-3 (CHEMBL3690) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.17 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22344 | — | — | 1 | 5.89 |
| CHEMBL23977 | DIDEAZAFOLATE | — | 1 | 5.70 |
| CHEMBL22798 | — | — | 1 | 5.52 |
| CHEMBL22626 | — | — | 1 | 5.30 |
| CHEMBL422395 | — | — | 1 | 5.22 |
| CHEMBL23035 | — | — | 1 | 5.16 |
| CHEMBL25108 | — | — | 1 | 5.10 |
| CHEMBL25107 | — | — | 1 | 4.96 |
| CHEMBL22668 | — | — | 1 | 4.75 |
| CHEMBL282270 | — | — | 1 | 4.72 |
| CHEMBL415251 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22344 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL23977 | DIDEAZAFOLATE | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL22798 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL22626 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL422395 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL23035 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL25108 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL25107 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL22668 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL282270 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL415251 | — | Ki | = | 32000.0 | nM | 4.50 |