Assay Detail
Binding
CHEMBL681445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | lymphoma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Trifunctional purine biosynthetic protein adenosine-3 (CHEMBL3972) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.66 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22344 | — | — | 1 | 5.89 |
| CHEMBL23977 | DIDEAZAFOLATE | — | 1 | 5.70 |
| CHEMBL140448 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22344 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL23977 | DIDEAZAFOLATE | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL140448 | — | Ki | = | 4000.0 | nM | 5.40 |