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Assay Detail

CHEMBL681462

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Fructose-1,6-bisphosphatase (F16BPase) in human liver
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Liver
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site.
Wright SW, Carlo AA, Danley DE, Hageman DL, Karam GA, Mansour MN, McClure LD, Pandit J, Schulte GK, Treadway JL, Wang IK, Bauer PH.
Bioorg Med Chem Lett (2003) 13 : 2055 -2058
PubMed 12781194 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.68 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291851 1 6.00
CHEMBL65698 1 5.92
CHEMBL64351 1 5.82
CHEMBL417403 1 5.77
CHEMBL62997 1 5.66
CHEMBL31344 1 5.60
CHEMBL303080 1 5.60
CHEMBL64297 1 5.57
CHEMBL305359 1 5.16
CHEMBL62848 1 -
CHEMBL64643 1 -
CHEMBL66025 1 -
CHEMBL50502 1 -
CHEMBL292072 1 -
CHEMBL64680 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291851 IC50 = 1000.0 nM 6.00
CHEMBL65698 IC50 = 1200.0 nM 5.92
CHEMBL64351 IC50 = 1500.0 nM 5.82
CHEMBL417403 IC50 = 1700.0 nM 5.77
CHEMBL62997 IC50 = 2200.0 nM 5.66
CHEMBL31344 IC50 = 2500.0 nM 5.60
CHEMBL303080 IC50 = 2500.0 nM 5.60
CHEMBL64297 IC50 = 2700.0 nM 5.57
CHEMBL305359 IC50 = 7000.0 nM 5.16
CHEMBL62848 IC50 >> 10000.0 nM -
CHEMBL64643 IC50 >> 10000.0 nM -
CHEMBL66025 IC50 >> 10000.0 nM -
CHEMBL50502 IC50 >> 10000.0 nM -
CHEMBL292072 IC50 >> 10000.0 nM -
CHEMBL64680 IC50 >> 10000.0 nM -