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Assay Detail

CHEMBL681463

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Fructose-1,6-bisphosphatase (F16BPase) in porcine kidney
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Kidney
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Fructose-1,6-bisphosphatase 1 (CHEMBL2263)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site.
Wright SW, Carlo AA, Danley DE, Hageman DL, Karam GA, Mansour MN, McClure LD, Pandit J, Schulte GK, Treadway JL, Wang IK, Bauer PH.
Bioorg Med Chem Lett (2003) 13 : 2055 -2058
PubMed 12781194 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.00 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL31344 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL31344 IC50 = 1000.0 nM 6.00