Assay Detail
Functional
CHEMBL681652
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EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Potent and orally bioavailable noncysteine-containing inhibitors of protein farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 8.82 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10877 | — | — | 1 | 10.00 |
| CHEMBL10902 | — | — | 1 | 9.52 |
| CHEMBL276602 | — | — | 1 | 9.11 |
| CHEMBL11210 | — | — | 1 | 9.05 |
| CHEMBL428001 | — | — | 1 | 8.92 |
| CHEMBL273697 | — | — | 1 | 8.82 |
| CHEMBL10990 | — | — | 1 | 8.74 |
| CHEMBL11195 | — | — | 1 | 8.00 |
| CHEMBL11003 | — | — | 1 | 8.00 |
| CHEMBL430096 | — | — | 1 | 8.00 |
| CHEMBL10762 | — | — | 1 | - |
| CHEMBL10970 | — | — | 1 | - |
| CHEMBL10687 | — | — | 1 | - |
| CHEMBL417606 | — | — | 1 | - |
| CHEMBL430307 | — | — | 1 | - |
| CHEMBL273265 | — | — | 1 | - |
| CHEMBL10812 | — | — | 1 | - |
| CHEMBL10955 | — | — | 1 | - |
| CHEMBL273721 | — | — | 1 | - |
| CHEMBL10912 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10877 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL10902 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL276602 | — | EC50 | = | 0.78 | nM | 9.11 |
| CHEMBL11210 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL428001 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL273697 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL10990 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL11195 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL11003 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL430096 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL10762 | — | EC50 | > | 0.3 | nM | - |
| CHEMBL10970 | — | EC50 | > | 1.0 | nM | - |
| CHEMBL10687 | — | EC50 | > | 1.0 | nM | - |
| CHEMBL417606 | — | EC50 | > | 1.0 | nM | - |
| CHEMBL430307 | — | EC50 | > | 1.0 | nM | - |
| CHEMBL273265 | — | EC50 | > | 1.0 | nM | - |
| CHEMBL10812 | — | EC50 | = | - | nM | - |
| CHEMBL10955 | — | EC50 | > | 1.0 | nM | - |
| CHEMBL273721 | — | EC50 | > | 1.0 | nM | - |
| CHEMBL10912 | — | EC50 | > | 0.3 | nM | - |