Assay Detail
Binding
CHEMBL681803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity was evaluated against farnesyltransferase (FTase)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Potent and orally bioavailable noncysteine-containing inhibitors of protein farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.32 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274122 | — | — | 1 | 9.40 |
| CHEMBL54044 | — | — | 1 | 9.30 |
| CHEMBL10877 | — | — | 1 | 9.15 |
| CHEMBL417606 | — | — | 1 | 8.92 |
| CHEMBL273697 | — | — | 1 | 8.82 |
| CHEMBL10912 | — | — | 1 | 8.62 |
| CHEMBL11210 | — | — | 1 | 8.59 |
| CHEMBL276602 | — | — | 1 | 8.54 |
| CHEMBL10990 | — | — | 1 | 8.54 |
| CHEMBL428001 | — | — | 1 | 8.52 |
| CHEMBL430296 | — | — | 1 | 8.52 |
| CHEMBL10812 | — | — | 1 | 8.31 |
| CHEMBL10955 | — | — | 1 | 8.22 |
| CHEMBL430096 | — | — | 1 | 8.22 |
| CHEMBL11003 | — | — | 1 | 8.21 |
| CHEMBL10970 | — | — | 1 | 8.20 |
| CHEMBL10902 | — | — | 1 | 8.19 |
| CHEMBL430307 | — | — | 1 | 8.18 |
| CHEMBL11195 | — | — | 1 | 8.12 |
| CHEMBL273265 | — | — | 1 | 8.08 |
| CHEMBL273507 | — | — | 1 | 8.06 |
| CHEMBL274672 | — | — | 1 | 8.00 |
| CHEMBL273721 | — | — | 1 | 7.92 |
| CHEMBL10762 | — | — | 1 | 7.72 |
| CHEMBL10687 | — | — | 1 | 7.70 |
| CHEMBL10572 | — | — | 1 | 6.25 |
| CHEMBL266618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274122 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL54044 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL10877 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL417606 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL273697 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL10912 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL11210 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL276602 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL10990 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL428001 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL430296 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL10812 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL10955 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL430096 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL11003 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL10970 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL10902 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL430307 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL11195 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL273265 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL273507 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL274672 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL273721 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL10762 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL10687 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL10572 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL266618 | — | IC50 | > | 1000.0 | nM | - |