Assay Detail
Binding
CHEMBL681811
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Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferase
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.61 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39324 | — | — | 2 | 9.30 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 9.10 |
| CHEMBL289529 | — | — | 1 | 9.00 |
| CHEMBL38080 | — | — | 1 | 8.80 |
| CHEMBL290745 | — | — | 1 | 8.77 |
| CHEMBL288853 | — | — | 1 | 8.46 |
| CHEMBL288693 | — | — | 1 | 8.40 |
| CHEMBL290833 | — | — | 1 | 8.22 |
| CHEMBL39274 | — | — | 1 | 8.22 |
| CHEMBL40088 | — | — | 1 | 8.19 |
| CHEMBL289417 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39324 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL39324 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL289529 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL38080 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL290745 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL288853 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL288693 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL290833 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL39274 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL40088 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL289417 | — | IC50 | = | 29.0 | nM | 7.54 |