Assay Detail
Binding
CHEMBL681887
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The concentration required to displace 50% of a highly potent radiolabeled FPTase inhibitor
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.07 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59963 | — | — | 1 | 9.07 |
| CHEMBL293623 | — | — | 1 | 8.95 |
| CHEMBL64183 | — | — | 1 | 8.66 |
| CHEMBL303326 | — | — | 2 | 8.40 |
| CHEMBL63107 | — | — | 1 | 8.35 |
| CHEMBL291580 | — | — | 1 | 8.10 |
| CHEMBL418513 | — | — | 1 | 8.06 |
| CHEMBL63106 | — | — | 1 | 8.04 |
| CHEMBL305138 | — | — | 1 | 7.96 |
| CHEMBL63270 | — | — | 1 | 7.92 |
| CHEMBL304703 | — | — | 1 | 7.89 |
| CHEMBL304449 | — | — | 1 | 7.20 |
| CHEMBL293924 | — | — | 1 | 6.78 |
| CHEMBL293015 | — | — | 1 | - |
| CHEMBL302429 | — | — | 1 | - |
| CHEMBL64168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59963 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL293623 | — | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL64183 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL303326 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL63107 | — | IC50 | = | 4.52 | nM | 8.35 |
| CHEMBL291580 | — | IC50 | = | 7.95 | nM | 8.10 |
| CHEMBL418513 | — | IC50 | = | 8.67 | nM | 8.06 |
| CHEMBL63106 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL305138 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL63270 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL304703 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL303326 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL304449 | — | IC50 | = | 62.9 | nM | 7.20 |
| CHEMBL293924 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL302429 | — | IC50 | - | nM | - | |
| CHEMBL64168 | — | IC50 | - | nM | - | |
| CHEMBL293015 | — | IC50 | - | nM | - |