Assay Detail
Binding
CHEMBL681892
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Inhibitory concentration against Trypanosoma brucei farnesyl pyrophosphate synthase activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.62 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55264 | — | — | 1 | 6.18 |
| CHEMBL299988 | — | — | 1 | 5.51 |
| CHEMBL298547 | — | — | 1 | 5.45 |
| CHEMBL110971 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55264 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL299988 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL298547 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL110971 | — | IC50 | = | 4540.0 | nM | 5.34 |