Assay Detail
Binding
CHEMBL681894
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Inhibition of Trypanosoma cruzi farnesyl pyrophosphate synthase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.17 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299988 | — | — | 1 | 5.71 |
| CHEMBL55264 | — | — | 1 | 5.62 |
| CHEMBL111695 | — | — | 1 | 5.37 |
| CHEMBL322081 | — | — | 1 | 5.34 |
| CHEMBL280463 | — | — | 1 | 5.25 |
| CHEMBL322551 | — | — | 1 | 5.24 |
| CHEMBL110971 | — | — | 1 | 5.07 |
| CHEMBL298547 | — | — | 1 | 5.03 |
| CHEMBL324003 | — | — | 1 | 4.71 |
| CHEMBL52761 | — | — | 1 | 4.37 |
| CHEMBL111593 | — | — | 1 | - |
| CHEMBL112840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299988 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL55264 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL111695 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL322081 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL280463 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL322551 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL110971 | — | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL298547 | — | IC50 | = | 9360.0 | nM | 5.03 |
| CHEMBL324003 | — | IC50 | = | 19730.0 | nM | 4.71 |
| CHEMBL52761 | — | IC50 | = | 42830.0 | nM | 4.37 |
| CHEMBL111593 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL112840 | — | IC50 | = | 150360.0 | nM | - |