Assay Detail
Binding
CHEMBL681895
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Binding affinity towards Trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.16 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55264 | — | — | 1 | 6.62 |
| CHEMBL111695 | — | — | 1 | 6.51 |
| CHEMBL299988 | — | — | 1 | 6.40 |
| CHEMBL280463 | — | — | 1 | 6.33 |
| CHEMBL322081 | — | — | 1 | 6.27 |
| CHEMBL110971 | — | — | 1 | 6.23 |
| CHEMBL298547 | — | — | 1 | 6.01 |
| CHEMBL324003 | — | — | 1 | 5.73 |
| CHEMBL52761 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55264 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL111695 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL299988 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL280463 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL322081 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL110971 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL298547 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL324003 | — | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL52761 | — | Ki | = | 5040.0 | nM | 5.30 |