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Assay Detail

CHEMBL682026

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of factor Xa
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors.
Dominguez C, Duffy DE, Han Q, Alexander RS, Galemmo RA, Park JM, Wong PC, Amparo EC, Knabb RM, Luettgen J, Wexler RR.
Bioorg Med Chem Lett (1999) 9 : 925 -930
PubMed 10230612 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.68 10.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290376 1 10.35
CHEMBL422722 1 6.40
CHEMBL174008 1 5.92
CHEMBL175398 1 5.62
CHEMBL173612 1 5.54
CHEMBL366643 1 5.52
CHEMBL171390 1 5.48
CHEMBL177038 1 5.02
CHEMBL174456 1 4.99
CHEMBL170063 1 4.96
CHEMBL173765 1 4.80
CHEMBL367626 1 4.64
CHEMBL368131 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290376 Ki = 0.045 nM 10.35
CHEMBL422722 Ki = 400.0 nM 6.40
CHEMBL174008 Ki = 1200.0 nM 5.92
CHEMBL175398 Ki = 2400.0 nM 5.62
CHEMBL173612 Ki = 2900.0 nM 5.54
CHEMBL366643 Ki = 3000.0 nM 5.52
CHEMBL171390 Ki = 3300.0 nM 5.48
CHEMBL177038 Ki = 9500.0 nM 5.02
CHEMBL174456 Ki = 10300.0 nM 4.99
CHEMBL170063 Ki = 11000.0 nM 4.96
CHEMBL173765 Ki = 16000.0 nM 4.80
CHEMBL367626 Ki = 23000.0 nM 4.64
CHEMBL368131 Ki = 25000.0 nM 4.60