Assay Detail
Binding
CHEMBL682028
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Inhibitory activity against Falcipain-2
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.62 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120254 | — | — | 1 | 5.36 |
| CHEMBL117767 | — | — | 1 | 5.04 |
| CHEMBL118355 | — | — | 1 | 5.03 |
| CHEMBL118210 | — | — | 1 | 4.88 |
| CHEMBL324722 | — | — | 1 | 4.66 |
| CHEMBL119370 | — | — | 1 | 4.54 |
| CHEMBL418861 | — | — | 1 | 4.53 |
| CHEMBL333067 | — | — | 1 | 4.51 |
| CHEMBL119213 | — | — | 1 | 4.48 |
| CHEMBL120076 | — | — | 1 | 4.46 |
| CHEMBL333137 | — | — | 1 | 4.41 |
| CHEMBL119756 | — | — | 1 | 4.41 |
| CHEMBL118305 | 5-NITROISATIN | — | 1 | 4.37 |
| CHEMBL119345 | — | — | 1 | 4.36 |
| CHEMBL336693 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120254 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL117767 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL118355 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL118210 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL324722 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL119370 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL418861 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL333067 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL119213 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL120076 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL333137 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL119756 | — | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL118305 | 5-NITROISATIN | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL119345 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL336693 | — | IC50 | = | 46900.0 | nM | 4.33 |