Assay Detail
Binding
CHEMBL682061
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Inhibition of Farnesyltransferase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.30 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328773 | — | — | 1 | 9.22 |
| CHEMBL90471 | — | — | 1 | 9.10 |
| CHEMBL275378 | — | — | 1 | 8.52 |
| CHEMBL93335 | — | — | 1 | 6.89 |
| CHEMBL93624 | — | — | 1 | 6.32 |
| CHEMBL92336 | — | — | 1 | 6.24 |
| CHEMBL93918 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328773 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL90471 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL275378 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL93335 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL93624 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL92336 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL93918 | — | IC50 | = | 15000.0 | nM | 4.82 |