Assay Detail
Binding
CHEMBL682065
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Inhibition of Farnesyltransferase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.16 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41748 | — | — | 1 | 9.52 |
| CHEMBL43631 | — | — | 1 | 9.40 |
| CHEMBL351706 | BMS-214662 | 1.0 | 1 | 9.15 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 9.05 |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | 8.70 |
| CHEMBL279433 | L-778123 FREE BASE | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41748 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL43631 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL351706 | BMS-214662 | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL298734 | LONAFARNIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL279433 | L-778123 FREE BASE | IC50 | = | 2.0 | nM | - |