Assay Detail
Functional
CHEMBL682148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for cytotoxicity against FM3A mouse mammary cells.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FM3A |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.84 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479432 | FEBRIFUGINE | — | 1 | 6.77 |
| CHEMBL105789 | ISOFEBRIFUGINE | — | 1 | 6.75 |
| CHEMBL110619 | — | — | 1 | 6.42 |
| CHEMBL107040 | — | — | 1 | 5.62 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 5.00 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479432 | FEBRIFUGINE | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL105789 | ISOFEBRIFUGINE | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL110619 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL107040 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 32000.0 | nM | 4.50 |