Assay Detail
Binding
CHEMBL682237
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Inhibition of Farnesyltransferase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.62 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90471 | — | — | 1 | 9.10 |
| CHEMBL331976 | — | — | 1 | 8.47 |
| CHEMBL334004 | — | — | 1 | 8.36 |
| CHEMBL333700 | — | — | 1 | 8.18 |
| CHEMBL121454 | — | — | 1 | 7.70 |
| CHEMBL333444 | — | — | 1 | 7.55 |
| CHEMBL119685 | — | — | 1 | 7.08 |
| CHEMBL440520 | — | — | 1 | 6.94 |
| CHEMBL333870 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90471 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL331976 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL334004 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL333700 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL121454 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL333444 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL119685 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL440520 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL333870 | — | IC50 | = | 6800.0 | nM | 5.17 |