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Assay Detail

CHEMBL682313

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human ERG potassium ion channel was determined
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Publication

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.
Caldwell CG, Chen P, He J, Parmee ER, Leiting B, Marsilio F, Patel RA, Wu JK, Eiermann GJ, Petrov A, He H, Lyons KA, Thornberry NA, Weber AE.
Bioorg Med Chem Lett (2004) 14 : 1265 -1268
PubMed 14980678 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 4.71 5.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25211 1 5.55
CHEMBL423108 1 5.28
CHEMBL281178 1 5.26
CHEMBL23979 1 5.24
CHEMBL22359 1 5.23
CHEMBL281561 1 5.22
CHEMBL23110 1 4.80
CHEMBL23660 1 4.72
CHEMBL23223 1 4.55
CHEMBL278558 1 4.54
CHEMBL25437 1 4.46
CHEMBL23891 1 4.43
CHEMBL283368 1 4.41
CHEMBL22679 1 4.40
CHEMBL279944 1 4.38
CHEMBL277693 1 4.37
CHEMBL22310 1 4.31
CHEMBL283309 1 4.28
CHEMBL23924 1 4.14
CHEMBL280658 1 -
CHEMBL23981 1 -
CHEMBL22511 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25211 Ki = 2800.0 nM 5.55
CHEMBL423108 Ki = 5300.0 nM 5.28
CHEMBL281178 Ki = 5500.0 nM 5.26
CHEMBL23979 Ki = 5700.0 nM 5.24
CHEMBL22359 Ki = 5900.0 nM 5.23
CHEMBL281561 Ki = 6000.0 nM 5.22
CHEMBL23110 Ki = 16000.0 nM 4.80
CHEMBL23660 Ki = 19000.0 nM 4.72
CHEMBL23223 Ki = 28000.0 nM 4.55
CHEMBL278558 Ki = 29000.0 nM 4.54
CHEMBL25437 Ki = 35000.0 nM 4.46
CHEMBL23891 Ki = 37000.0 nM 4.43
CHEMBL283368 Ki = 39000.0 nM 4.41
CHEMBL22679 Ki = 40000.0 nM 4.40
CHEMBL279944 Ki = 42000.0 nM 4.38
CHEMBL277693 Ki = 43000.0 nM 4.37
CHEMBL22310 Ki = 49000.0 nM 4.31
CHEMBL283309 Ki = 52000.0 nM 4.28
CHEMBL23924 Ki = 73000.0 nM 4.14
CHEMBL280658 Ki > 90000.0 nM -
CHEMBL23981 Ki > 90000.0 nM -
CHEMBL22511 Ki > 90000.0 nM -