Assay Detail
Binding
CHEMBL682420
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Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by Farnesyltransferase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.76 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252953 | — | — | 1 | 9.82 |
| CHEMBL322355 | — | — | 1 | 9.82 |
| CHEMBL324081 | — | — | 1 | 9.80 |
| CHEMBL115502 | — | — | 1 | 9.39 |
| CHEMBL326210 | — | — | 1 | 9.35 |
| CHEMBL114739 | — | — | 1 | 9.26 |
| CHEMBL325396 | — | — | 1 | 8.55 |
| CHEMBL325840 | — | — | 1 | 8.55 |
| CHEMBL114990 | — | — | 1 | 8.40 |
| CHEMBL326745 | — | — | 1 | 8.00 |
| CHEMBL320244 | — | — | 1 | 7.13 |
| CHEMBL324008 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252953 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL322355 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL324081 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL115502 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL326210 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL114739 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL325396 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL325840 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL114990 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL326745 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL320244 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL324008 | — | IC50 | = | 82.0 | nM | 7.09 |