Assay Detail
Binding
CHEMBL682558
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Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzolactams as non-peptide cholecystokinin receptor ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.87 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445095 | — | — | 1 | 9.30 |
| CHEMBL342640 | — | — | 1 | 8.59 |
| CHEMBL38404 | — | — | 1 | 8.48 |
| CHEMBL34335 | — | — | 1 | 7.75 |
| CHEMBL423278 | — | — | 1 | 7.58 |
| CHEMBL170293 | — | — | 1 | 7.43 |
| CHEMBL424211 | — | — | 1 | 6.92 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 6.52 |
| CHEMBL168386 | — | — | 1 | 6.34 |
| CHEMBL355319 | — | — | 1 | 6.32 |
| CHEMBL169807 | — | — | 1 | 6.21 |
| CHEMBL171722 | — | — | 1 | 5.60 |
| CHEMBL169931 | — | — | 1 | 5.51 |
| CHEMBL169794 | — | — | 1 | 5.27 |
| CHEMBL170068 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445095 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL342640 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL38404 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL34335 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL423278 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL170293 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL424211 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL168386 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL355319 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL169807 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL171722 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL169931 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL169794 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL170068 | — | IC50 | = | 5500.0 | nM | 5.26 |