Assay Detail
Binding
CHEMBL682622
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Trifunctional purine biosynthetic protein adenosine-3 (CHEMBL3690) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.03 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38902 | — | — | 1 | 7.33 |
| CHEMBL417696 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38902 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL417696 | — | Ki | = | 190.0 | nM | 6.72 |