Assay Detail
Binding
CHEMBL682645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=100 micro<M
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-1/beta-3/gamma-2 (CHEMBL2094121) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Alpha-amino acid phenolic ester derivatives: novel water-soluble general anesthetic agents which allosterically modulate GABA(A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.26 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526 | PROPOFOL | 4.0 | 1 | 5.39 |
| CHEMBL331192 | — | — | 1 | 5.39 |
| CHEMBL116662 | — | — | 1 | 5.26 |
| CHEMBL13254 | ORG-24447 | — | 1 | 5.00 |
| CHEMBL544583 | — | — | 1 | - |
| CHEMBL120361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526 | PROPOFOL | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL331192 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL116662 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL13254 | ORG-24447 | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL544583 | — | EC50 | = | 198000.0 | nM | - |
| CHEMBL120361 | — | EC50 | > | 100000.0 | nM | - |