Assay Detail
Functional
CHEMBL682809
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Tested in vivo for the inhibition of proliferation of friend leukemic cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Friend leukemia cell line |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.95 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.40 |
| CHEMBL113003 | — | — | 1 | 6.08 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.00 |
| CHEMBL113337 | — | — | 1 | 5.28 |
| CHEMBL115271 | — | — | 1 | 5.23 |
| CHEMBL112652 | — | — | 1 | 5.21 |
| CHEMBL323695 | — | — | 1 | 4.96 |
| CHEMBL264629 | — | — | 1 | 4.89 |
| CHEMBL46941 | — | — | 1 | 4.82 |
| CHEMBL110906 | — | — | 1 | 4.82 |
| CHEMBL111993 | — | — | 1 | 4.82 |
| CHEMBL331150 | — | — | 1 | 4.66 |
| CHEMBL109960 | — | — | 1 | 4.55 |
| CHEMBL112728 | — | — | 1 | 4.46 |
| CHEMBL419029 | — | — | 1 | 4.24 |
| CHEMBL326022 | — | — | 1 | 4.19 |
| CHEMBL113095 | — | — | 1 | 4.16 |
| CHEMBL320038 | — | — | 1 | 4.14 |
| CHEMBL111919 | — | — | 1 | 4.12 |
| CHEMBL325733 | — | — | 1 | - |
| CHEMBL326617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL113003 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL113337 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL115271 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL112652 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL323695 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL264629 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL46941 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL110906 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL111993 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL331150 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL109960 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL112728 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL419029 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL326022 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL113095 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL320038 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL111919 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL325733 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL326617 | — | IC50 | > | 100000.0 | nM | - |