Assay Detail
Binding
CHEMBL682871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellum
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Felis catus |
| Tissue | Cerebellum |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.74 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112203 | — | — | 1 | 8.62 |
| CHEMBL112710 | — | — | 1 | 8.18 |
| CHEMBL301742 | ARBACLOFEN | 3.0 | 1 | 7.82 |
| CHEMBL113453 | — | — | 1 | 7.75 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 7.60 |
| CHEMBL701 | BACLOFEN | 4.0 | 1 | 7.46 |
| CHEMBL113217 | — | — | 1 | 6.55 |
| CHEMBL113907 | — | — | 1 | 6.30 |
| CHEMBL111920 | — | — | 1 | 6.11 |
| CHEMBL111675 | — | — | 1 | 6.04 |
| CHEMBL325921 | — | — | 1 | 5.87 |
| CHEMBL302213 | — | — | 1 | 5.75 |
| CHEMBL324917 | — | — | 1 | 5.36 |
| CHEMBL112960 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112203 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL112710 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL301742 | ARBACLOFEN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL113453 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL701 | BACLOFEN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL113217 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL113907 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL111920 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL111675 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL325921 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL302213 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL324917 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL112960 | — | IC50 | = | 12800.0 | nM | 4.89 |