Assay Detail
Binding
CHEMBL682932
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In vitro inhibition of [3H]FPP incorporation into H-Ras-CVLS by Farnesyl transferase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.22 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27449 | — | — | 1 | 6.69 |
| CHEMBL26923 | — | — | 1 | 6.52 |
| CHEMBL27002 | — | — | 1 | 6.05 |
| CHEMBL281738 | — | — | 1 | 5.89 |
| CHEMBL26246 | — | — | 1 | 5.27 |
| CHEMBL26771 | — | — | 1 | 5.10 |
| CHEMBL28367 | — | — | 1 | 5.00 |
| CHEMBL285129 | — | — | 1 | 4.34 |
| CHEMBL26720 | — | — | 1 | 4.30 |
| CHEMBL282814 | — | — | 1 | 4.24 |
| CHEMBL282297 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27449 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL26923 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL27002 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL281738 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL26246 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL26771 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL28367 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL285129 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL26720 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL282814 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL282297 | — | IC50 | = | 100000.0 | nM | 4.00 |