Assay Detail
Binding
CHEMBL682935
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In vitro inhibitory activity against farnesyl transferase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.78 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417481 | — | — | 1 | 9.25 |
| CHEMBL29356 | — | — | 1 | 9.15 |
| CHEMBL29980 | — | — | 1 | 9.04 |
| CHEMBL280976 | — | — | 1 | 8.92 |
| CHEMBL282793 | — | — | 1 | 8.60 |
| CHEMBL29946 | — | — | 1 | 6.89 |
| CHEMBL29748 | — | — | 1 | 6.62 |
| CHEMBL25968 | — | — | 1 | 6.55 |
| CHEMBL282964 | — | — | 1 | 6.51 |
| CHEMBL29466 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417481 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL29356 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL29980 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL280976 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL282793 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL29946 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL29748 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL25968 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL282964 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL29466 | — | IC50 | = | 560.0 | nM | 6.25 |