Assay Detail
Binding
CHEMBL682940
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Inhibition of human FTase-catalyzed incorporation of [3H]FPP into recombinant Ras CVIM
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 9.01 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23578 | — | — | 1 | 10.10 |
| CHEMBL24733 | — | — | 1 | 9.55 |
| CHEMBL22702 | — | — | 2 | 9.43 |
| CHEMBL24123 | — | — | 1 | 9.39 |
| CHEMBL22703 | — | — | 1 | 9.18 |
| CHEMBL25620 | — | — | 1 | 9.17 |
| CHEMBL26068 | — | — | 1 | 9.16 |
| CHEMBL418018 | — | — | 1 | 9.15 |
| CHEMBL24554 | — | — | 1 | 9.15 |
| CHEMBL23370 | — | — | 1 | 9.15 |
| CHEMBL24043 | — | — | 1 | 9.14 |
| CHEMBL24271 | — | — | 1 | 9.10 |
| CHEMBL283051 | — | — | 1 | 9.10 |
| CHEMBL282349 | — | — | 1 | 9.08 |
| CHEMBL23753 | — | — | 1 | 9.00 |
| CHEMBL24159 | — | — | 1 | 9.00 |
| CHEMBL26511 | — | — | 1 | 8.96 |
| CHEMBL277646 | — | — | 1 | 8.85 |
| CHEMBL24822 | — | — | 1 | 8.48 |
| CHEMBL25621 | — | — | 1 | 8.22 |
| CHEMBL24048 | — | — | 1 | 7.92 |
| CHEMBL26492 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23578 | — | IC50 | = | 0.079 | nM | 10.10 |
| CHEMBL24733 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL22702 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL22702 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL24123 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL22703 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL25620 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL26068 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL418018 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL24554 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL23370 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL24043 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL24271 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL283051 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL282349 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL23753 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL24159 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL26511 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL277646 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL24822 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL25621 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL24048 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL26492 | — | IC50 | = | 33.0 | nM | 7.48 |