Assay Detail
Functional
CHEMBL682997
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In vitro nicotinic activity was measured on frog rectus abdominis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | frog |
| Tissue | Rectus abdominis muscle |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.86 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.42 |
| CHEMBL553214 | — | — | 1 | 5.30 |
| CHEMBL540395 | — | — | 1 | 4.54 |
| CHEMBL554629 | — | — | 1 | 4.18 |
| CHEMBL541927 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14 | CARBACHOL | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL553214 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL540395 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL554629 | — | EC50 | = | 66200.0 | nM | 4.18 |
| CHEMBL541927 | — | EC50 | = | 2600000.0 | nM | - |