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Assay Detail

CHEMBL683002

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Binding
Inhibitory concentration against human Glycogen synthase kinase-3
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Glycogen synthase kinase-3 beta (CHEMBL262)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors.
Naerum L, Nørskov-Lauritsen L, Olesen PH.
Bioorg Med Chem Lett (2002) 12 : 1525 -1528
PubMed 12031334 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.41 6.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL288064 1 6.41
CHEMBL40021 1 6.09
CHEMBL37689 1 5.96
CHEMBL37342 1 5.92
CHEMBL37811 1 5.85
CHEMBL40439 1 5.17
CHEMBL416975 1 5.10
CHEMBL290211 1 4.96
CHEMBL40004 1 4.92
CHEMBL290436 1 4.54
CHEMBL40022 1 4.54
CHEMBL37826 1 -
CHEMBL288588 1 -
CHEMBL39357 1 -
CHEMBL37652 1 -
CHEMBL40842 1 -
CHEMBL39803 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL288064 IC50 = 390.0 nM 6.41
CHEMBL40021 IC50 = 820.0 nM 6.09
CHEMBL37689 IC50 = 1100.0 nM 5.96
CHEMBL37342 IC50 = 1200.0 nM 5.92
CHEMBL37811 IC50 = 1400.0 nM 5.85
CHEMBL40439 IC50 = 6700.0 nM 5.17
CHEMBL416975 IC50 = 8000.0 nM 5.10
CHEMBL290211 IC50 = 11000.0 nM 4.96
CHEMBL40004 IC50 = 12000.0 nM 4.92
CHEMBL290436 IC50 = 29000.0 nM 4.54
CHEMBL40022 IC50 = 29000.0 nM 4.54
CHEMBL37826 IC50 > 250000.0 nM -
CHEMBL288588 IC50 = 235000.0 nM -
CHEMBL39357 IC50 > 250000.0 nM -
CHEMBL37652 IC50 = 198000.0 nM -
CHEMBL40842 IC50 > 250000.0 nM -
CHEMBL39803 IC50 > 250000.0 nM -