Assay Detail
Binding
CHEMBL683005
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Inhibition of porcine GSK-3-alpha/beta kinase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.03 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321194 | — | — | 1 | 6.70 |
| CHEMBL326919 | — | — | 1 | 6.26 |
| CHEMBL321192 | — | — | 1 | 6.22 |
| CHEMBL111624 | — | — | 1 | 6.10 |
| CHEMBL111433 | — | — | 1 | 6.10 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | 5.60 |
| CHEMBL114396 | — | — | 1 | 5.22 |
| CHEMBL109622 | — | — | 1 | - |
| CHEMBL599552 | INDIGO | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321194 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL326919 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL321192 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL111624 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL111433 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1276127 | INDIRUBIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL114396 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL109622 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL599552 | INDIGO | IC50 | > | 100000.0 | nM | - |