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Assay Detail

CHEMBL683023

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards [3H]Fnz in alpha-1-beta-2-gamma-2 subtype was measured
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Expert

Target

GABA A receptor alpha-3/beta-2/gamma-2 (CHEMBL2111339)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex.
Jacobsen EJ, TenBrink RE, Stelzer LS, Belonga KL, Carter DB, Im HK, Im WB, Sethy VH, Tang AH, VonVoigtlander PF, Petke JD.
J Med Chem (1996) 39 : 158 -175
PubMed 8568803 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.70 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL48403 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL48403 Ki = 2.0 nM 8.70