Assay Detail
Binding
CHEMBL683024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flunitrazepam from GABA-A receptor alpha-3-beta-2-gamma-2 subunits expressed in Sf9 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
GABA A receptor alpha-3/beta-2/gamma-2 (CHEMBL2111339) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.55 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50763 | — | — | 1 | 9.29 |
| CHEMBL290036 | — | — | 1 | 9.15 |
| CHEMBL279867 | PANADIPLON | 2.0 | 1 | 8.24 |
| CHEMBL48211 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50763 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL290036 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL279867 | PANADIPLON | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL48211 | — | Ki | = | 30.0 | nM | 7.52 |