Assay Detail
Binding
CHEMBL683100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMF
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Breast |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.63 | 10.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68055 | ACOLBIFENE | 3.0 | 1 | 10.12 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 9.95 |
| CHEMBL1222035 | — | — | 1 | 8.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68055 | ACOLBIFENE | Ki | = | 0.076 | nM | 10.12 |
| CHEMBL135 | ESTRADIOL | Ki | = | 0.113 | nM | 9.95 |
| CHEMBL1222035 | — | Ki | = | 1.53 | nM | 8.81 |