Assay Detail
Functional
CHEMBL683469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 6.22 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282915 | — | — | 1 | 9.18 |
| CHEMBL273330 | — | — | 1 | 8.64 |
| CHEMBL143209 | — | — | 1 | 8.41 |
| CHEMBL19340 | — | — | 1 | 8.33 |
| CHEMBL278503 | — | — | 1 | 8.28 |
| CHEMBL217163 | — | — | 1 | 8.27 |
| CHEMBL263957 | — | — | 1 | 8.00 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.82 |
| CHEMBL142943 | — | — | 1 | 7.35 |
| CHEMBL141072 | — | — | 1 | 7.23 |
| CHEMBL23553 | — | — | 1 | 7.12 |
| CHEMBL22964 | — | — | 1 | 7.11 |
| CHEMBL291238 | — | — | 1 | 6.24 |
| CHEMBL359450 | — | — | 1 | 6.24 |
| CHEMBL45857 | BETULIN-3,28-DIOXIME | — | 1 | 5.97 |
| CHEMBL143038 | — | — | 1 | 5.97 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 5.85 |
| CHEMBL139830 | — | — | 1 | 5.80 |
| CHEMBL139822 | — | — | 1 | 5.68 |
| CHEMBL7365 | — | — | 1 | 5.57 |
| CHEMBL143332 | — | — | 1 | 5.53 |
| CHEMBL140040 | 3-EPI-BETULIN | — | 1 | 5.44 |
| CHEMBL266914 | — | — | 1 | 5.44 |
| CHEMBL142269 | — | — | 1 | 5.42 |
| CHEMBL140308 | — | — | 1 | 5.42 |
| CHEMBL434805 | — | — | 1 | 5.37 |
| CHEMBL140917 | — | — | 1 | 5.34 |
| CHEMBL143577 | — | — | 1 | 5.33 |
| CHEMBL140528 | — | — | 1 | 5.32 |
| CHEMBL23554 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282915 | — | EC50 | = | 0.66 | nM | 9.18 |
| CHEMBL273330 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL143209 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL19340 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL278503 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL217163 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL263957 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL142943 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL141072 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL23553 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL22964 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL291238 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL359450 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL143038 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL45857 | BETULIN-3,28-DIOXIME | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL269277 | BETULINIC ACID | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL139830 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL139822 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL7365 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL143332 | — | EC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL266914 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL140040 | 3-EPI-BETULIN | EC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL142269 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL140308 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL434805 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL140917 | — | EC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL143577 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL140528 | — | EC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL23554 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL346410 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL16738 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL356672 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL278574 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL23236 | BETULIN | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL297478 | BETULONAL | EC50 | = | 45600.0 | nM | 4.34 |
| CHEMBL141717 | 30-HYDROXY-BETULIN | EC50 | = | 50800.0 | nM | 4.29 |
| CHEMBL143494 | — | EC50 | > | 13800.0 | nM | - |
| CHEMBL404519 | BEVIRIMAT | EC50 | < | 0.35 | nM | - |
| CHEMBL359080 | BETULIN DIACETATE | EC50 | > | 189800.0 | nM | - |