Assay Detail
Binding
CHEMBL683487
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Inhibition of Geranylgeranyl transferase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.42 | 4.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41934 | — | — | 1 | 4.42 |
| CHEMBL39153 | — | — | 1 | - |
| CHEMBL41473 | — | — | 1 | - |
| CHEMBL416231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41934 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL39153 | — | IC50 | > | 38000.0 | nM | - |
| CHEMBL41473 | — | IC50 | > | 38000.0 | nM | - |
| CHEMBL416231 | — | IC50 | > | 33000.0 | nM | - |