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Assay Detail

CHEMBL683543

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [125I]fibrinogen binding to human Fibrinogen Receptor.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Integrin alpha-IIb/beta-3 (CHEMBL2093869)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation.
Sanfilippo PJ, Urbanski MJ, Beers KN, Eckardt A, Falotico R, Ginsberg MH, Offord S, Press JB, Tighe J, Tomko K.
J Med Chem (1995) 38 : 34 -41
PubMed 7837237 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.77 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL131216 1 5.89
CHEMBL336617 1 5.39
CHEMBL265628 1 5.10
CHEMBL129921 1 5.05
CHEMBL335492 1 5.00
CHEMBL131557 1 4.95
CHEMBL543666 1 4.91
CHEMBL337874 1 4.81
CHEMBL130674 1 4.76
CHEMBL543903 1 4.74
CHEMBL557202 1 4.64
CHEMBL334808 1 4.60
CHEMBL334831 1 4.52
CHEMBL132168 1 4.40
CHEMBL131809 1 4.35
CHEMBL133562 1 4.30
CHEMBL334815 1 4.30
CHEMBL335070 1 4.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL131216 IC50 = 1300.0 nM 5.89
CHEMBL336617 IC50 = 4100.0 nM 5.39
CHEMBL265628 IC50 = 7900.0 nM 5.10
CHEMBL129921 IC50 = 9000.0 nM 5.05
CHEMBL335492 IC50 = 10000.0 nM 5.00
CHEMBL131557 IC50 = 11200.0 nM 4.95
CHEMBL543666 IC50 = 12300.0 nM 4.91
CHEMBL337874 IC50 = 15600.0 nM 4.81
CHEMBL130674 IC50 = 17500.0 nM 4.76
CHEMBL543903 IC50 = 18300.0 nM 4.74
CHEMBL557202 IC50 = 23000.0 nM 4.64
CHEMBL334808 IC50 = 25000.0 nM 4.60
CHEMBL334831 IC50 = 30000.0 nM 4.52
CHEMBL132168 IC50 = 40000.0 nM 4.40
CHEMBL131809 IC50 = 45000.0 nM 4.35
CHEMBL133562 IC50 = 50000.0 nM 4.30
CHEMBL334815 IC50 = 50000.0 nM 4.30
CHEMBL335070 IC50 = 70000.0 nM 4.16