Assay Detail
Functional
CHEMBL683566
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Tested for inhibition of thumping behavior in gerbils induced by iv administration of SP-methyl ester 2 hours after peroral administration of 30 mg/kg of the compound
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Gerbillinae |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.68 | 7.68 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSE | DOSE | 30.0 | mg.kg-1 | — |
| ROUTE | ROUTE | - | — | Oral |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295122 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295122 | — | IC50 | = | 21.0 | nM | 7.68 |