Assay Detail
Functional
CHEMBL683615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human squamous cell carcinoma FaDu cells during continuous Exposure (0-12 h)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | FaDu |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.08 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.95 |
| CHEMBL430872 | — | — | 1 | 7.76 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | — | 1 | 7.26 |
| CHEMBL106628 | — | — | 1 | 6.90 |
| CHEMBL323565 | — | — | 1 | 6.75 |
| CHEMBL1237205 | — | — | 1 | 5.85 |
| CHEMBL2092925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | EC50 | = | 11.3 | nM | 7.95 |
| CHEMBL430872 | — | EC50 | = | 17.5 | nM | 7.76 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL106628 | — | EC50 | = | 126.0 | nM | 6.90 |
| CHEMBL323565 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1237205 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2092925 | — | EC50 | > | 10000.0 | nM | - |