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Assay Detail

CHEMBL683625

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antiviral activity against 460.2 clone of HXB2 mutant virus in their protease sequence
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Human immunodeficiency virus type 1 protease (CHEMBL243)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
Sham HL, Zhao C, Stewart KD, Betebenner DA, Lin S, Park CH, Kong XP, Rosenbrook W, Herrin T, Madigan D, Vasavanonda S, Lyons N, Molla A, Saldivar A, Marsh KC, McDonald E, Wideburg NE, Denissen JF, Robins T, Kempf DJ, Plattner JJ, Norbeck DW.
J Med Chem (1996) 39 : 392 -397
PubMed 8558507 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 7.68 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL443030 1 7.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL443030 EC50 = 21.0 nM 7.68