Assay Detail
Binding
CHEMBL683628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity to inhibit mutant HIV-1 rRT activity in Y181C
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.88 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84217 | — | — | 1 | 6.96 |
| CHEMBL85059 | — | — | 1 | 6.89 |
| CHEMBL283950 | L-737126 | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84217 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL85059 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL283950 | L-737126 | IC50 | = | 160.0 | nM | 6.80 |