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Assay Detail

CHEMBL684059

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of Trypanosoma cruzi GAPDH.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 0 — Uncurated / Unknown
Curated By Expert

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.
Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH.
J Med Chem (2001) 44 : 2080 -2093
PubMed 11405646 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.82 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL63338 1 5.30
CHEMBL303342 1 5.16
CHEMBL303595 1 5.16
CHEMBL303934 1 5.16
CHEMBL291418 1 5.00
CHEMBL303751 1 5.00
CHEMBL63403 1 4.92
CHEMBL431169 1 4.92
CHEMBL303752 1 4.92
CHEMBL63569 1 4.92
CHEMBL464924 1 4.92
CHEMBL303730 1 4.85
CHEMBL65460 1 4.52
CHEMBL291088 1 4.40
CHEMBL64311 1 4.40
CHEMBL62124 1 4.30
CHEMBL294813 1 4.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL63338 IC50 = 5000.0 nM 5.30
CHEMBL303342 IC50 = 7000.0 nM 5.16
CHEMBL303595 IC50 = 7000.0 nM 5.16
CHEMBL303934 IC50 = 7000.0 nM 5.16
CHEMBL291418 IC50 = 10000.0 nM 5.00
CHEMBL303751 IC50 = 10000.0 nM 5.00
CHEMBL63403 IC50 = 12000.0 nM 4.92
CHEMBL431169 IC50 = 12000.0 nM 4.92
CHEMBL303752 IC50 = 12000.0 nM 4.92
CHEMBL63569 IC50 = 12000.0 nM 4.92
CHEMBL464924 IC50 = 12000.0 nM 4.92
CHEMBL303730 IC50 = 14000.0 nM 4.85
CHEMBL65460 IC50 = 30000.0 nM 4.52
CHEMBL291088 IC50 = 40000.0 nM 4.40
CHEMBL64311 IC50 = 40000.0 nM 4.40
CHEMBL62124 IC50 = 50000.0 nM 4.30
CHEMBL294813 IC50 = 75000.0 nM 4.12