Assay Detail
Binding
CHEMBL684061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound against glyceraldehyde-3-phosphate dehydrogenase was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glyceraldehyde-3-phosphate dehydrogenase (CHEMBL2284) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.22 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3559427 | — | — | 1 | 7.00 |
| CHEMBL307758 | — | — | 1 | 5.30 |
| CHEMBL71742 | — | — | 1 | 4.92 |
| CHEMBL2408380 | — | — | 1 | 4.54 |
| CHEMBL3142239 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3559427 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL307758 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL71742 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2408380 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3142239 | — | IC50 | = | 45000.0 | nM | 4.35 |