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Assay Detail

CHEMBL684062

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Binding
Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Glyceraldehyde-3-phosphate dehydrogenase (CHEMBL2284)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase.
Leitão A, Andricopulo AD, Oliva G, Pupo MT, de Marchi AA, Vieira PC, da Silva MF, Ferreira VF, de Souza MC, Sá MM, Moraes VR, Montanari CA.
Bioorg Med Chem Lett (2004) 14 : 2199 -2204
PubMed 15081008 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.34 4.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67818 1 4.77
CHEMBL67599 1 4.75
CHEMBL69085 1 4.51
CHEMBL71271 1 4.41
CHEMBL303027 1 4.28
CHEMBL1231470 CHALEPIN 1 4.26
CHEMBL67979 1 4.25
CHEMBL419813 1 4.25
CHEMBL70378 1 4.19
CHEMBL71407 1 4.17
CHEMBL302011 1 4.13
CHEMBL305426 1 4.07
CHEMBL70732 1 -
CHEMBL6466 COUMARIN 4.0 1 -
CHEMBL71358 SESALIN 1 -
CHEMBL306160 1 -
CHEMBL421484 1 -
CHEMBL52229 OSTHOLE 1 -
CHEMBL305510 1 -
CHEMBL306543 1 -
CHEMBL71850 1 -
CHEMBL303846 XANTHYLETIN 1 -
CHEMBL51628 UMBELLIFERONE 1 -
CHEMBL71851 SCOPOLETIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67818 IC50 = 16982.44 nM 4.77
CHEMBL67599 IC50 = 17782.79 nM 4.75
CHEMBL69085 IC50 = 30902.95 nM 4.51
CHEMBL71271 IC50 = 38904.51 nM 4.41
CHEMBL303027 IC50 = 52480.75 nM 4.28
CHEMBL1231470 CHALEPIN IC50 = 54954.09 nM 4.26
CHEMBL67979 IC50 = 56234.13 nM 4.25
CHEMBL419813 IC50 = 56234.13 nM 4.25
CHEMBL70378 IC50 = 64565.42 nM 4.19
CHEMBL71407 IC50 = 67608.3 nM 4.17
CHEMBL302011 IC50 = 74131.02 nM 4.13
CHEMBL305426 IC50 = 85113.8 nM 4.07
CHEMBL70732 IC50 = 123026.88 nM -
CHEMBL6466 COUMARIN IC50 = 691830.97 nM -
CHEMBL71358 SESALIN IC50 = 123026.88 nM -
CHEMBL306160 IC50 = 128824.96 nM -
CHEMBL421484 IC50 = 346736.85 nM -
CHEMBL52229 OSTHOLE IC50 = 208929.61 nM -
CHEMBL305510 IC50 = 190546.07 nM -
CHEMBL306543 IC50 = 144543.98 nM -
CHEMBL71850 IC50 = 162181.01 nM -
CHEMBL303846 XANTHYLETIN IC50 = 194984.46 nM -
CHEMBL51628 UMBELLIFERONE IC50 = 616595.0 nM -
CHEMBL71851 SCOPOLETIN IC50 = 257039.58 nM -