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Assay Detail

CHEMBL684101

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Functional
Inhibitory activity against HIV-1 replication in H9 lymphocytes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type H9
Confidence 1 — Organism
Curated By Intermediate

Target

H9 (CHEMBL614806)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone analogues.
Xie L, Takeuchi Y, Cosentino LM, McPhail AT, Lee KH.
J Med Chem (2001) 44 : 664 -671
PubMed 11262077 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 5.40 5.81

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL161501 1 5.81
CHEMBL431573 1 5.74
CHEMBL350999 1 5.72
CHEMBL161542 1 5.70
CHEMBL423428 1 5.67
CHEMBL269559 1 5.59
CHEMBL349334 1 5.38
CHEMBL129 ZIDOVUDINE 4.0 1 5.35
CHEMBL161576 1 5.33
CHEMBL352285 1 5.14
CHEMBL349225 1 5.04
CHEMBL435860 1 4.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL161501 EC50 = 1540.0 nM 5.81
CHEMBL431573 EC50 = 1830.0 nM 5.74
CHEMBL350999 EC50 = 1920.0 nM 5.72
CHEMBL161542 EC50 = 2010.0 nM 5.70
CHEMBL423428 EC50 = 2120.0 nM 5.67
CHEMBL269559 EC50 = 2560.0 nM 5.59
CHEMBL349334 EC50 = 4190.0 nM 5.38
CHEMBL129 ZIDOVUDINE EC50 = 4500.0 nM 5.35
CHEMBL161576 EC50 = 4690.0 nM 5.33
CHEMBL352285 EC50 = 7210.0 nM 5.14
CHEMBL349225 EC50 = 9100.0 nM 5.04
CHEMBL435860 EC50 = 43700.0 nM 4.36