Assay Detail
Functional
CHEMBL684138
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Inhibitory activity against H460pv8 cell line using MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.51 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.40 |
| CHEMBL41700 | — | — | 1 | 7.30 |
| CHEMBL43453 | — | — | 1 | 6.89 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.70 |
| CHEMBL41526 | — | — | 1 | 6.50 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.41 |
| CHEMBL38451 | — | — | 1 | 6.31 |
| CHEMBL291263 | — | — | 1 | 5.99 |
| CHEMBL41174 | — | — | 1 | 5.96 |
| CHEMBL43229 | — | — | 1 | 5.69 |
| CHEMBL41863 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL41700 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL43453 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL43 | AMSACRINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL41526 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL38451 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL291263 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL41174 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL43229 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL41863 | — | IC50 | = | 3770.0 | nM | 5.42 |