Assay Detail
Functional
CHEMBL684255
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Compound is screened for cell growth inhibition against GC3/MTK-cell line, a human thymidine kinase deficient adenocarcinoma line
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GC3/MTK- |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.29 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55263 | — | — | 1 | 6.22 |
| CHEMBL9440 | METESIND | 2.0 | 1 | 6.05 |
| CHEMBL56523 | — | — | 1 | 5.96 |
| CHEMBL57420 | — | — | 1 | 5.68 |
| CHEMBL59203 | — | — | 1 | 5.44 |
| CHEMBL55884 | — | — | 1 | 5.32 |
| CHEMBL293823 | — | — | 1 | 5.30 |
| CHEMBL56611 | — | — | 1 | 5.19 |
| CHEMBL434980 | — | — | 1 | 5.10 |
| CHEMBL293810 | — | — | 1 | 5.00 |
| CHEMBL294871 | — | — | 1 | 4.96 |
| CHEMBL56637 | — | — | 1 | 4.94 |
| CHEMBL301218 | — | — | 1 | 4.92 |
| CHEMBL55361 | — | — | 1 | 4.64 |
| CHEMBL417763 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55263 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL9440 | METESIND | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL56523 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL57420 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL59203 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL55884 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL293823 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL56611 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL434980 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL293810 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL294871 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL56637 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL301218 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL55361 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL417763 | — | IC50 | = | 26000.0 | nM | 4.58 |