Assay Detail
Functional
CHEMBL684257
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Compound was tested for the inhibition of thymidine kinase deficient human adenocarcinoma GC3M(-) cell growth
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GC3M(-) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.08 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171057 | — | — | 1 | 5.52 |
| CHEMBL169727 | — | — | 1 | 5.39 |
| CHEMBL168524 | — | — | 1 | 5.07 |
| CHEMBL171314 | — | — | 1 | 5.05 |
| CHEMBL353700 | — | — | 1 | 4.37 |
| CHEMBL353813 | — | — | 1 | - |
| CHEMBL352620 | — | — | 1 | - |
| CHEMBL172176 | — | — | 1 | - |
| CHEMBL169726 | — | — | 1 | - |
| CHEMBL353191 | — | — | 1 | - |
| CHEMBL56662 | — | — | 1 | - |
| CHEMBL301256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171057 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL169727 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL168524 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL171314 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL353700 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL353813 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL352620 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL172176 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL169726 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL353191 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL56662 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL301256 | — | IC50 | > | 5000.0 | nM | - |